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Wednesday, 25 June 2014

IV Semester BSC Genetics

    IV Semester (Molecular Genetics)

1. Chemical basis of Heredity
      - DNA as genetic material, Experiment of Griffith, Avery, MacLeod, Mc Carry & Hard hey chase
       - RNA as genetic Material-Experiment of Frankel & Singer

2. Nucleic Acids
     - DNA structure & Types
     - RNA structure & Types
     - Ribozymes

3.DNA Replication
     - DNA replication in prokaryotes & Rolling circle Model
     - DNA replication in Eukaryotes

4. Gene Expression
     - Genetic code: Brief introduction
     - protein synthesis in prokaryotes & Eukaryotes translation
                -- Transcription ("rho" dependent & "rho" independent Termination)
                -- Post transcriptional modifications
               -- Translation
     - Regulation of Gene Expression
               --- inducible operons-Galactose
               --- Repressible operon - Tryptophan

5. Genome organisation & fine structure of the gene
        - Prokaryotic genome - chromosomal & plasmid
        - Eukaryotic genome-chromosomal & organellar
        - Fine structure of the Gene - Cistron, Moton & Recon



6. Transposable elements
       -- Maize & Drosophila

7. Bacterial Genetics
       -- Transformation
       -- Transduction - Generalized & specialized
       -- Conjugation - F- Factor mediated, Hfr & sexduction

8. Mutations
      -- Introduction & Types of Gene Mutation - Base substitution, Frame shift mutation ( insertion, deletion, missence, nonsense mutation)
      -- Mutagens - Physical & chemical
      -- Reverse mutation in bacteria, DNA repair mechanism (mismatch repair, photoreactivation, Excision & SOS repair).
     -- Beneficial & harmful effects of mutation.

9. Introduction to Genomic & Proteomics.

CLICK REFERENCE

Genetics

Paper 6 Human Genetics
   
    BIOCHEMISTRY





































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