Semester VI paper VII advance Genetic
1. Development Genetics:
Factors controlling development. Nuclear changes during development (Nuclear transplantation) Switching genes on and off during development. Fate mapping; Tissue specific methylation. Differential expression of haemoglobingenes.
The genetics of development in Drosophila and arabidopsis.
Homoetic genes in genetic control of flower. Flower morphogenesis (Rice and Arabidopsis thaliana)
2. Evolutionary Genetics:
Mutation theory: Neo Darwinism; Synthetic Theory. Evolution at molecular level; Nucleotide sequence. Speciation; Races and Specied, Methods of speciation
3. Population Genetics:
Gene pool and gene frequencies: Hardy- Weinvberg principle, Evolutionary agents: Selection-differential selection, fitness, gametic selection, zygotic selection; Migration and Random drift.
Biometrical Genetics
a) Quanhtitative characters:
Description of continuous variation in quantitative or economic characters in crop plants and animals: Grain/Crop yield, Milk yield, Egg size and number. Litter size in pigs, Wool yield and Body weight in sheep
b) Quantitative inheritance:
Features of polygenic traits in relation to oligogenic traits. Inheritance of Kernel color in wheat, Ear length in maize, body size in rabbits and poultry and skin colour in human. Transgressive inheritance. Assumptions of polygenic inheritance. Environmental effects
c) Partitioning of polygenic variability
phenotypic & genotypic and environmental variability. Additive Variance, Dominance variance and Epistatic variance
d) Phenotypic & Genotypic coefficients of Variation (PCV & GCV)
Heritability in broad sense, Genetic advance, genotypic and phenotypic correlations. Path coefficient analysis. Selection index
Significance of polygenic inheritance in evolution and improvement of crop varieties as well as animal breeds.
e) Cancer Genetic:
Regulation of mitotic cell cycle in eukaryotes and intercellular communication in multi cellular eukaryotes. properties of cancer cells. Proto oncogenes, oncogenes, Cellular oncogenes, Tumor suppressor genes, Viral oncogenes.
Chromosomal abnormalities associated with the specific malignancies-CML,APL,ALL, ANLL,CLL & Retinoblastoma.
f) Introduction to Genomics and Proteomics:
PAPER VIII APPLIED GENETICS
1. Recombinant DNA Technology Application in medicine & Industry:
Producton of recombinant insulin, interferon & human growth hormone (HGH), antibiotics, steroid drugs, and vaccines. Preparation of DNA probes, monoclonal antibodies and diagnostic kits.
DNA finger printing
Recovery of DNA, Restriction digestion and Electrophoresis (RFLP & RAPD), Southern blotting, Autoradiography and matching with known marker bands. Application: Forensic Science, Medico-legal, Wildlife and Plant Science.
2. Genetic Resources:
Germplasm, classificaton, Germplasm activities, Organizations associated with germplasm (NBPGR, National Facility of Drosophila)
Center of Diversity and Gene Bank
Introduction, Genetic Erosion, Biodiversity, Centers of Diversity, Vavilovian Centers of Diversity, Law of parallelism, Gene Sanctuaries, Gene Bank and Cyro-preservation.
3. Hoterosis breeding in Animals:
4. Identification of Hybrid plants:
Phenotypic identificaton of Hybrid plants using Gene marks and computation of Genetic Purity Pot Culturing.
Parents and Hybrids of crops such as Cotton, Chilies, Onion, Tomato, etc, (Source: KSSCA, Bangalore and IIHR, Hesaragatta).
6. Study Tour to premier Plant and/or Animal Breeding Centres.
1. Development Genetics:
Factors controlling development. Nuclear changes during development (Nuclear transplantation) Switching genes on and off during development. Fate mapping; Tissue specific methylation. Differential expression of haemoglobingenes.
The genetics of development in Drosophila and arabidopsis.
Homoetic genes in genetic control of flower. Flower morphogenesis (Rice and Arabidopsis thaliana)
2. Evolutionary Genetics:
Mutation theory: Neo Darwinism; Synthetic Theory. Evolution at molecular level; Nucleotide sequence. Speciation; Races and Specied, Methods of speciation
3. Population Genetics:
Gene pool and gene frequencies: Hardy- Weinvberg principle, Evolutionary agents: Selection-differential selection, fitness, gametic selection, zygotic selection; Migration and Random drift.
Biometrical Genetics
a) Quanhtitative characters:
Description of continuous variation in quantitative or economic characters in crop plants and animals: Grain/Crop yield, Milk yield, Egg size and number. Litter size in pigs, Wool yield and Body weight in sheep
b) Quantitative inheritance:
Features of polygenic traits in relation to oligogenic traits. Inheritance of Kernel color in wheat, Ear length in maize, body size in rabbits and poultry and skin colour in human. Transgressive inheritance. Assumptions of polygenic inheritance. Environmental effects
c) Partitioning of polygenic variability
phenotypic & genotypic and environmental variability. Additive Variance, Dominance variance and Epistatic variance
d) Phenotypic & Genotypic coefficients of Variation (PCV & GCV)
Heritability in broad sense, Genetic advance, genotypic and phenotypic correlations. Path coefficient analysis. Selection index
Significance of polygenic inheritance in evolution and improvement of crop varieties as well as animal breeds.
e) Cancer Genetic:
Regulation of mitotic cell cycle in eukaryotes and intercellular communication in multi cellular eukaryotes. properties of cancer cells. Proto oncogenes, oncogenes, Cellular oncogenes, Tumor suppressor genes, Viral oncogenes.
Chromosomal abnormalities associated with the specific malignancies-CML,APL,ALL, ANLL,CLL & Retinoblastoma.
f) Introduction to Genomics and Proteomics:
PAPER VIII APPLIED GENETICS
1. Recombinant DNA Technology Application in medicine & Industry:
Producton of recombinant insulin, interferon & human growth hormone (HGH), antibiotics, steroid drugs, and vaccines. Preparation of DNA probes, monoclonal antibodies and diagnostic kits.
DNA finger printing
Recovery of DNA, Restriction digestion and Electrophoresis (RFLP & RAPD), Southern blotting, Autoradiography and matching with known marker bands. Application: Forensic Science, Medico-legal, Wildlife and Plant Science.
2. Genetic Resources:
Germplasm, classificaton, Germplasm activities, Organizations associated with germplasm (NBPGR, National Facility of Drosophila)
Center of Diversity and Gene Bank
Introduction, Genetic Erosion, Biodiversity, Centers of Diversity, Vavilovian Centers of Diversity, Law of parallelism, Gene Sanctuaries, Gene Bank and Cyro-preservation.
3. Hoterosis breeding in Animals:
4. Identification of Hybrid plants:
Phenotypic identificaton of Hybrid plants using Gene marks and computation of Genetic Purity Pot Culturing.
Parents and Hybrids of crops such as Cotton, Chilies, Onion, Tomato, etc, (Source: KSSCA, Bangalore and IIHR, Hesaragatta).
6. Study Tour to premier Plant and/or Animal Breeding Centres.
CLICK REFERENCE
Genetics
Paper 6 Human
Genetics
Paper8 Genetics
(Applied Genetics)
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